An inducible Cre transgenic mouse useful for analysing gene function in sensory neurons
Pdgfra-CreER(T2) transgenic mice
This is a dual-reporter mouse line Sox10-lox-eGFP-STOP-lox-tdTomato (referred to as Sox10-GFP/td-Tom), designed for studies of oligodendrocyte (OL) lineage cells and generated by PAC transgenesis. Recombination under the influence of Cre leads to the expression of tdTomato instead of GFP. A majority of OL lineage cells (95%) in the corpus callosum expresses the transgene.
Sox10-iCreERT2. Codon-improved version of CreERT2 expressed under the transcriptional control of Sox10 sequences in a PAC. This is designed to express in myelinating cells of the CNS and PNS (oligodendrocytes and Schwann cells, respectively) following tamoxifen administration. Pre-natal tamoxifen might also induce expression in migratory neural crest cells, although this has not been tested.