BMI-1 transduced basal epithelial cells

Primary, human airway basal epithelial cells transduced with the anti-senescence gene BMI1. Cells have been validated for differentiation on air-liquid interface cultures, demonstrating mucus production, ciliation, and other features of airway epithelium. Basal cells can be passaged at least 20 times, retaining their differentiation capacity.

Cells are provided in cryovials on dry ice and should be stored in liquid nitrogen for long term storage. Basal cells can be maintained and differentiated on ALI, in specialised media from commercial suppliers (e.g., Lonza, Pneumacult, Promocell, Epithelix). We now routinely use Pneumacult media.

Cells available include; 

NHBE – nasal or tracheal 

PCD DNAH5

For commercial use, please contact us to discuss licensing options.

Full acknowledgement of the source of the BMI-1 cells must be given in all relevant publications and presentations of research results. The following statement must be included in all publications and the accompanying reference must be cited:

'The human BMI-1 transduced basal epithelial cell line (BMI-1) was obtained from the UCL Institute of Child Health, London, UK.'

The reference is:

"Munye, M.M., et al (2017) BMI-1 extends proliferative potential of human bronchial epithelial cells while retaining their mucociliary differentiation capacity, Am J Physiol Lung Cell Mol Physiol, 312(2), L258-L267"

Placing an order on XIP

To license this product, please select the appropriate licence option on the right-hand side of this page. Terms can be previewed from the "Preview terms" link.

MTAs require agreement between all the parties involved in supplying and receiving a product. This cannot happen instantaneously but is a controlled process, managed through XIP and should not take longer no than 10 business days in ordinary circumstances.

To place an order, please locate the Sign-in or Register options on the top right side of this page. You can either sign in to your existing account or register for a new now. Please note that your account should be created using your academic/ institutional e-mail address.

For additional guidance on how to create an account and place an order, refer to the FAQs.