Abysis is a complete system for loading, storing and analysing public and proprietary antibody sequences and 3D structures. The loading software pairs light and heavy chains and ensures that all antibody sequences are numbered in the universally recognised forms (such as Kabat or Chothia). It then performs other key assessments prior to loading into an SQL database. The interface provides many key facilities including the analysis of residue and length distributions as well as a number of antibody-specific sequence analysis tools.

All public antibody sequence and structure data are already available in Abysis at www.abysis.org; researchers are encouraged to make use of this freely available webservice and become familiar with the database features available. Upgrading to the commercially licensed version available here as a software download gives a number of key benefits to researchers, in particular the ability to keep their proprietary antibody sequences in-house for integration with public data and analysis using the Abysis system.

By loading both publicly available and proprietary data, a comprehensive view of the antibody world can be obtained through use of the unified and standardised numbering schemes. Users are then able to interrogate the database either through the Abysis interface or by writing their own programs (in SQL) to query the underlying database.

All antibody sequences are stored with standardised numbering schemes including the popular Kabat and Chothia systems, as well as others. The interface enables researchers to additionally analyse sequences not held in the database and ask important questions regarding antibody humanisation.

Further information can be found at www.abysis.org.

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