Description:
A bacterial artificial chromosome (BAC) transgenic line that expresses tamoxifen-inducible Cre recombinase in Fgfr3-expressing cells throughout the body, including astrocytes in the CNS, neural stem cells in the SVZ, hippocampus and spinal cord ependymal zone, and inner ear cells (organ of Corti).
References:
Young, K.M., Mitsumori, T., Pringle, N., Grist, M., Kessaris, N. and Richardson, W.D. (2010). An Fgfr3-iCreERT2 transgenic line for studies of astrocytes and neural stem cells in the mouse CNS. Glia 58, 943-953.
Anttonen, T., Kirjavainen, A., Belevich, I., Laos, M., Richardson, W.D., Jokitalo, E., Brakebusch, C. and Pirvola, U. (2012). Cdc42-dependent structural development of auditory supporting cells is required for wound healing in adulthood. Sci. Rep. 2, 978. doi: 10.1038/srep00978
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File name:iCre genotyping protocol.pdf
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| File size:6.40 KB |
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File description:Publication
File name:Young et al (Glia 2010).pdf
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| File size:957.61 KB |
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Anttonen, T., Kirjavainen, A., Belevich, I., Laos, M., Richardson, W.D., Jokitalo, E., Brakebusch, C., Pirvola, U. (2012).
Cdc42-dependent structural development of auditory supporting cells is required for wound healing in adulthood, Sci. Rep., 2, 978. doi: 10.1038/srep00978.
Young, K.M., Mitsumori, T., Pringle, N., Grist, M., Kessaris, N., Richardson, W.D. (2010).
An Fgfr3-iCreERT2 transgenic line for studies of astrocytes and neural stem cells in the mouse CNS, Gila, 58, 943-953.
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